Comparative evaluation of the effectiveness of systemic and local administration of mesenchymal stem cells in experimental neuropathy

Objective. Compare the effectiveness of systemic and local administration adipose-derived mesenchymal stem cells (ADMSC) at a dose 1х106 cells/kg on nociceptive sensitivity to mechanical thermal stimuli in rats changes histostructure sciatic nerve surrounded tissues affected hind paw experimental model peripheral neuropathy nerve. Materials methods. 26 male Wistar were used perform by axotomy On 7th day, animals underwent or transplantation ADMSC 1x10 6 cells/kg. Nociceptive responses assessed for 90 days, surrounding was analyzed after ADMSC. Results. Systemic with increased withdrawal threshold (MWT) 17.1% had no effect latency (TWL). Local ADMSCs an equivalent contributed full recovery MWT TWL 21 st day experiment, as well suppressed inflammatory reaction soft operated animals. Conclusion. Intramuscular into area significantly more effective than cell transplant. This method is appropriate further studies mechanisms antinociceptive reparative effects ADMSCs.